Although bones vary greatly in size and shape, they have certain structural similarities. Bones have cells embedded in a mineralized (calcium) matrix and collagen fibers. Compact bone forms the shafts of long bones; it also occurs on the outer side of the bone. Spongy bone forms the inner layer.

    Human heart Compact bone has a series of Haversian canals around which concentric layers of bone cells (osteocytes) and minerals occur. New bone is formed by the osteocytes. The Haversian canals form a network of blood vessels and nerves that nourish and monitor the osteocytes.

    Spongy bone occurs at the ends of long bones and is less dense than compact bone. The spongy bone of the femur, humerus, and sternum contains red marrow, in which stem cells reproduce and form the cellular components of the blood and immune system. Yellow marrow, at the center of these bones, is used to store fats. The outer layer of the bones is known as the periosteum. The inner layer of the periosteum forms new bone or modifies existing bone to meet new conditions. It is rich in nerve endings and blood and lymphatic vessels. When fractures occur, the pain is carried to the brain by nerves running through the periosteum.

    Endochondral ossification is the process of converting the cartilage in embryonic skeletons into bone. Cartilage is deposited early in development into shapes resembling the bones-to-be. Cells inside this cartilage grow and begin depositing minerals.

    The spongy bone forms, and osteoblasts attach and lay down the mineral portions of spongy bone. Osteoclasts remove material from the center of the bone, forming the central cavity of the long bones. The perichondrium, a connective tissue, forms around the cartilage and begins forming compact bone while the above changes are occurring. Blood vessels form and grow into the perichondrium, transporting stem cells into the interior. Two bands of cartilage remain as the bone develops, one at each end of the bone. During childhood, this cartilage allows for growth and changes in the shape of bones. Eventually the elongation of the bones stops and the cartilage is all converted into bone.

    Bones continue to change as adults, to adapt to the stresses generated by physical activity. Exercise can increase the diameter and strength of bone; inactivity can decrease them. Age is a factor: osteoporosis is a disease that primarily affects older, postmenopausal women. Increasing calcium intake, reducing protein intake, exercise and low doses of estrogen are effective treatments for osteoporosis.

    There are three types of joints: immovable, partly movable, and synovial. Immovable joints, like those connecting the cranial bones, have edges that tightly interlock. Partly movable joints allow some degree of flexibility and usually have cartilage between the bones; example: vertebrae. Synovial joints permit the greatest degree of flexibility and have the ends of bones covered with a connective tissue filled with synovial fluid; example: hip.

    The outer surface of the synovial joints contains ligaments that strengthen joints and hold bones in position. The inner surface (the synovial membrane) has cells producing synovial fluid that lubricates the joint and prevents the two cartilage caps on the bones from rubbing together. Some joints also have tendons (connective tissue linking muscles to bones). Bursae are small sacs filled with synovial fluid that reduce friction in the joint. The knee joint contains 13 bursae